Clarithromycin induced digoxin toxicity.

Clarithromycin induced digoxin toxicity: case report and review.

Drug interactions of some commonly used drugs in dermatology.

Table Drug interactions of some commonly used drugs in dermatology Drug interactions of some commonly used drugs in dermatology Drug interactions of some commonly used drugs in dermatology Drug interactions of some commonly used drugs in dermatology Drug interactions of some commonly used drugs in dermatology Drug interactions leading to serious adverse effects are to be cautiously watched for ...

Electrocardiographic manifestation of digoxin toxicity in a Pomeranian dog

This case report describes several electrocardiographic findings in an 8-years old female Pomeranian dog that was referred with a history of digoxin overdose. Electrocardiographic abnormalities detected in this case could be classified as primary electrocardiographic disturbances, reflecting cardiac chamber enlargement and secondary ECG changes, attributed to digoxin toxicity. ECG manifestatio...

A prospective study of the clarithromycin-digoxin interaction in elderly patients.

The study was a prospective observational trial carried out to assess the clarithromycin-digoxin interaction in elderly patients chronically taking digoxin. Digoxin concentrations were determined before and after concomitant treatment with clarithromycin. A Bayesian approach was used to calculate digoxin pharmacokinetics. In the seven patients who were studied there was a significant increase i...

Inhibition of P-glycoprotein-mediated efflux of digoxin and its metabolites by macrolide antibiotics.

This study was conducted to determine the rate of P-glycoprotein (P-gp)-mediated efflux of digoxin analogues and metabolites and to assess the effects of macrolide antibiotics on this efflux. Bidirectional transport studies were conducted using our Caco-2 sub clone with high P-gp expression (CLEFF9). HPLC methods were employed to measure drug transport. All digoxin metabolites were P-gp substra...